There are two primary "everyone hates you" mechanics, Disquiet and the Wasteland.
Disquiet is the torches and pitchforks mechanic. Prometheans are unnatural abominations, and every single human's lizard brain picks up on it and starts flipping out.
It's not too horrible, though. It's a contested Azoth (power stat) vs. Resolve+Composure roll, that happens whenever the human spends more than a few seconds around you. For every member of your throng that's of a different Lineage, you get a -1 to your Azoth roll, meaning it's entirely possible you're throwing a chance die. If the human succeeds on their roll, they're immune to your Disquiet for the scene.
When Disquiet
does take hold, it takes a while to get to the "burn down the castle" stage. It's until third stage (the third roll, if they succeed every time) that they actually are driven to act; before that, it's just dreams and fantasies. It's not until the final stage that Disquiet actually becomes infectious.
So, you're capable of interaction with people, but you probably can't maintain a face-to-face relationship (Frankenstein pen pals are a-OK). This, obviously, kind of sucks, but that's why most Prometheans want to stop being a Promethean. It is not, however, unplayable in any sense.
Wasteland is an extension of Disquiet. It's the effect you have on the land around you if you stop in one place for too long. This is supposed to emphasize the TV Hulk vibe; the default Promethean game is very much a road trip.
However, it is pretty much entirely toothless. When you stop to rest for an hour, it puts a mark on the landscape. If you stay within a mile of that mark for a full 24 hours, the Wasteland starts spreading.
Here's a map of downtown Detroit. Take a look at the scale and think about it. An average commute totally defeats a Wasteland. Owning two apartments and switching between them every night would allow you almost total safety, if you're worried about it.
Also, like Disquiet, it takes a while for a Wasteland to get up to steam, and by "a while" I mean weeks or months. A first stage Wasteland is literally undetectable. It has absolutely no effects on anything. From there, it takes an entire week of you hanging around that exact same mile-wide area for a stage two Wasteland to take hold. If you do this, you're kind of an idiot. Even if the stage two happens, it's still not that bad. It's not pleasant, but it's things like "water tastes kind of nasty" and "people look less healthy".
After that? You have to spend a
month hanging out in the mile-wide area plus a number of miles equal to your Azoth to spread it further.
So, actually causing a Wasteland of any actual bother pretty much requires the Promethean to not care in the slightest.