@ChaoticSky = Knowledge will definitely aid the cause in certain heretical areas.
@Darkaurora00 = The mechanics of the game and history remain unchanged
That said, I am a fan of a Rogue Trader and a Black Crusade rule. I will edit those additions into the initial post (see above)
@LCP = I trust each person to know their own situation best
I appreciate the honesty, but trust in your assessment of your future.