Re: Tips & tricks for generating/GMing in a modern real-Earth setting?
As Yora said, there is not much to generate, everything is already there. However, if you're the only one who's familiar with the area, you're not limited to what it's actually like, you can include or exclude things you feel would improve the game.
One thing I found really hard when running D20 Modern was to come up with plot hooks, as only medieval plot hooks came to mind. That, however, forced me to create a more open, player-driven campaign where each character had their own agenda, and I was only there to put obstacles in their way. However, a large overarching plot can also work.
One thing that might be interesting is to see how the supernatural interacts with the natural: do the mundanes know of supernatural things? Is it hidden, is it part of the rumors, is it an open, accepted thing? This is definitely what you'll have to think of when you design your campaign.