PrC's
River Warden: skillmonkey PrC with water themes.
Shadow Warrior: Soulborn/Shadowcaster gish.
SssSsSss: Incarnum using PrC for lizardfolk.
Apostate Sword: class based around not fighting. Probably not useful in a standard D&D game.
Scion of Awesome: You're so cool you make the universe forget that you shouldn't be able to do that.
Dissembler: As it turns out, some undead don't need to be all in one piece to be dangerous.
Channel of Ysgard: Incarnate PrC which is viking themed.
Cogitator: Warforged PrC based around executing your battle plan.
Unbound: Another Incarnum PrC, this one combines Factotum and Incarnate. There is also an epic destiny involved but... friends don't let friends play Epic.
Master of Marks: A skill based class which creates supernatural effects with runes. Most effective if given the chance to prepare a battlefield, an ambush, a robbery, etc ahead of time.
Goldbug: Turns money into power without the bother of magic items. Comes in direct engagement and manipulator/summoner varieties.
Phoenix Hunter: A ranger oriented PrC with various abilities to help v mythical firebirds.
Mystic Ninja: Warlock/Ninja hybrid, with the goal of making it easier to make ninjas from the movies using the ninja class.
Dream Warrior: It's like Combat Focus, but less terrible.
Promethean Psion: It's a caveman wielding a club that is also a psion. Not the caveman, the club.
Brilliant Paladin: Remember the Helm of Brilliance? This class makes it... less stupid to use.
Mythtaken: It's a bard who tells people that monsters aren't so scary. And they have powers to make it (sort of) true.
Marked One: Mark of Justice is normally a problem. This class makes it an opportunity.
Crucible: Have you ever wanted to purge evil with your fireballs, but your party members keep getting in the way? This class is for you.
Adept of Loki: Did you ever think that D&D needed more dice? This class has you roll for class features every level. And BAB, saves, skills... it's probably not a good idea to actually play it.
Base Classes
Pilot of Nothingness:Class based around calling a giant fighting robot.
Soulborn Remake: it's full BAB and full meldshaper level. And gets essentia from level
12.
Misc
Totemist Soulmelds
Incarnate Soulmelds
Another Incarnate Soulmeld: much more effective at healing than Lifebond Vestments.
Paladin Spells: most of these are useless for Archivists, which is good or bad, depending.
Human Paragon Substitution Levels: includes a vestige based on Theodore Roosevelt.
New uses for Sense Motive and Gather Information: exactly what it says on the tin.