1 Creed & Swarmlord (Warhammer 40k) vs 30 Fighter & Black mage (8 bit theatre) -- voting against rule of funny.
28 Ichigo & Aizen (Bleach) vs 7 Soviet Superman & Mister Rictus (Mark Millar) -- Rictus goes down immediately (again, *sigh*), but I think Red Superman can take out Team Bleach. He doesn't hold back like regular Supes does.
24 4th Hokage & Orochimaru (Naruto) vs 22 Samus & Dark Samus (Metroid) -- this could go either way, but I like power suits and guns more than weird anime attacks.
20 Alphamon & D-Reaper (Digimon) vs 18 Cohen the Barbarian & Granny Weatherwax (Discworld) -- Granny might be able to pull of some manipulation tricks, but I think Digimon takes this.
16 Megaman & Protoman (Mega Man) vs 14 Jack Rakan & Evangeline A.K McDowell (Mahou Sensei Negima) -- Robots go boom. Those MSN guys are monsters.
12 Hulk & Magneto (Marvel Universe) vs 23 Roland & Randall Flagg (Dark Tower) -- It was a good run, Dark Tower, but this is it. Either Marvel character could take these guys single-handedly.
25 Tom Strong & Kid Miracleman (Alan Moore) vs 6 Godzilla & MechaGodzilla (Godzilla) -- Finally, Tom Strong can get into the game! I'm on board with him subverting MechaGodzilla while Kid Miracleman keeps them busy. Then, it's giant-robotic-monster-powered Strong and KM versus Big G.
4 Gohan & Cooler (Dragonball) vs 2 Martian Manhunter & Doomsday (DC Universe) -- Doomsday has Dragonball-levels of physical power. J'onn J'onzz may be a bit below the curve here in strength (a weird thing to say, but probably true), but he has other abilities (mind powers, shapeshifting, intangibility) that can likely tip the scales for Team DC.