Of all the oWoD gamelines, I think it was Hunter: the Reckoning that was most influenced by the "Creation is WoD's past" conceit. The Imbued were supposed to be heirs to Solars somehow. I'm not sure how that was supposed to work.
Mind you, while I haven't read Imperial Mysteries, I choose to ignore the idea that each splat has a superpowered being or class of beings looking out for it. I prefer my nWoD without godlike beings playing it like chess.