It really is a delicate balance. I settle for the level of "Well THATS an issue". Its between "There are no consequences" and "Holy crap this guy is so frustrating to play". Use common sense and the law of "It would be really funny right now" as a guide.
Once again, I'll refer people to a more well made RPG, L5R 4e. In that disadvantages are mostly all mechanical, or at least provide some real penalties. Taking the Can't Lie disadvantage can cause real problems. Their not all perfect, but taking max points worth of disadvantages isn't an automatic in that system.
"Sometimes, we’re heroes. Sometimes, we shoot other people right in the face for money."