On the Myrtle in March thing:
After perusing a variety of travel options, I have three basic choices:
1) Pay $40 bucks to Greyhound up to and from Chicago then ~$260 for tickets to and from Myrtle. This constitutes the cheap and fast option, if incredibly inconvenient.
2) Fly straight from Indy for ~$430. Fast, convenient and a price to match.
3) Greyhound all the way. At $178 for the round trip, it is by far the cheapest option. Downsides include taking the Greyhoud at all and, of course, 20+ hour travel times.
So... unless somebody wants to hook me up with cheap flight tickets, it looks like Greyhound will win on the price factor alone.