For the most part the question is in the title. I know 5e is more noob-friendly than 3.5 is but the difficulty is that while I've played 3.5 for years and have a very strong working knowledge of the rules, monsters, balance issues, etc., I've never actually played a 5e game myself. I've read the rulebooks and I have a basic understanding of it, but nowhere near to the extent I have for 3.5. It's also really the first time I'm going to be DMing. Of the group of players I'll be DMing for, my wife is the only one who's played before and that was just one game of 3.5. Any advice or tips would be appreciated.