I've looked at its system from a tabletop perspective - and it's very, very unsuited. Just read the manual and count up the sheer number of dice rolls involves. There's something like 40-60 update steps per turn (depending on which Dominions you're using, and I don't really know the Dom 1 or Dom 2 systems well at all), some of which involve multiple rolls per province. The combat system routinely involves three opposed rolls per strike, (hit, repel, damage), before bringing in fear, awe, blood vengeance, shield penetration, wound effects, etc. and a lot of these are for whiffs.

Basically, there's a fundamental difference in the cost of rolling a die that leads to hugely variable systems. In a tabletop game, every die roll takes noticeable rolling time, noticeable calculation time, and noticeable mental effort. It's not a lot, but it can add up quickly, especially in something like opposed exploding 2d6 (or 2z5, if we're taking the -1 on explosion into account). For a computer it's basically nothing.