Quote Originally Posted by veti View Post
By the sound of it this is early in the game, when the best sniper weapon you can hope to be touting is the cowboy repeater, and you haven't yet had the chance to pick up any followers.
You can pick up Veronica as soon as you can find her.

At that point I've certainly had trouble with the hit squad, especially first time when I didn't know what to expect.

Even with foreknowledge, they're a tough challenge at that stage. My best advice would be, don't skimp. This is no time to be keeping anything in reserve - hit them with everything you have, as fast as possible.
Or climb up somewhere they can't follow, then shoot them from range. Works for most opponents.