Quote Originally Posted by Super_Fluous View Post
Fluff-wise, I like to play up the idea of just how old dragons can be.

Think about it. Individual dragons have lived eons before humanoid civilization sprang up, and they'll be alive and kicking far after we're gone. To a dragon, a human is barely a figment, less then ants or fleas are too us. We barely exist even for an equivalent second of their lifespans, and fade into nothingness. The sheer matter is that dragons simply do not care about us at all, unless we get in their immediate way. We are simply irrelevant by comparison.

Basically, play up the potential cosmic horror aspects of them. Dragons as Cthulhu, that sort of thing.
This works a lot better when the 'irrelevant figments' are not demonstrably capable of kicking the cosmic horrors asses to the Seven Heavens and back. This kind of situation in D&D is more Gurren Lagann than Cthulu.