Some people say that but I disagree to avoiding it (a GM should always have this thing out and refer to it in sesssion simply as a freak out tool
). The idea is, that you have hit a level where it is no longer a battle of individuals and it has become a battle of resources. Take a look at the skill lists for these Ascension classes. They are mostly reputation and relationship based, this is basiclly how you acquire openings to gain more allies as your opposition probably has many. I found classes like the Vindicare, Storm Trooper, and combat focused psykers particularly weak. They have little to no way of actually interacting with organisations outside of their comfort zone. Classes like the Sage, Magos, Interrogator however get to build some fairly strong alliances which can be used as their weapons.