Err, that's assuming you're playing the variety where you can't turn it off...
And from an apparently-D&D-centric perspective, as well.
For instance, let's say I'm playing Exalted, and for some reason, my Abyssal can't turn off his plague-powers. Chances are, said character will be
indifferent, at best. After all, if he's a loyalist, he's
already trying to destroy the world, and doesn't need the help of anyone living to do so, and if he's a renegade, then he's probably avoiding people anyway, so as not to inadverdently afflict them with his Resonance, and has appropriate Medicine Charms to keep everyone he
does have to interact with perfectly hale.