Acts of extreme evil, (hint: unjustly slaughtering hundreds of sentient beings including dragons, centaurs, etc. not for any good reason but for the explicit purpose of torture, and enjoying every death,) can push an alignment completely over.
What about Soon Kim, Girard Draketooth, Serini, all those guys? I don't think there is much point talking about all the characters Roy met in the LG afterlife...