Diablo III: Not Just a Vitality Race!

[AgentPaper]

How do you cast spells in the game? Press the corresponding number tab and point in that direction? Or just click and point?

By default, you can put two skills on your mouse buttons, and another five on the 1-5 keys. The fist two you click on an enemy to cast, or hold shift to hard-cast it. 1-5 you just press the button and it casts the spell at your mouse target.

You can also re-bind the extra slots to also be buttons on your mouse, though I haven't had to fiddle with that since my mouse already has a numpad on it that works for the number keys just fine.