Except that it has only 1/3 to 1/2 the range of missiles, and being in cover will protect you from it (a basic rule of 40k)
Small Correction. That's the difference in range between the 40K weapons. Samus missiles do not necessarily comply with the same range difference.

That depends, does Samus have a way of both surviving and traveling in open space?
Because in that case she would just have to blow the reactor on the hulk up, and then escape away before everything explodes.
Well if she gets her ship, Creed and the Swarmlord get a pod/shuttle. Otherwise no. Well not for very long. As far as I know her suit is space worthy but she would die of starvation.