I'm pretty sure that a strong case could be made for the time we shipped Nightmare Moon and Gummy...
Or the time where we decided that ponies who die become trees, making Fluttershy's statement of liking the idea of being a tree even more morbid.
Edit: Oh yeah, and the Midnight cloning facility that SiuiS is using to harvest organs (Especially spare pancreases) and for players in his role playing games. (Ha! And you thought we all forgot!)