Considering the fact that he killed a god before, with some prep time and highly powerful allies at his side against five of these Jenoine or gods, yeah I think he can make it stick. Besides, after this stupid duel he'll only have to worry about killing one of them, who'll probably be a little fatigued after tearing the other Big Bad to shreds. Of course he'll do the killing with Godslayer/Lady Teldra.
Edit: I was mistaken, Vlad didn't kill a gods because Jenoine and gods are different things. Jenoine are primordial beings of great sorcerous power who created the Dragoreans. Gods are acsended mortals.