The game does seem a bit harder then the first. But I also wasn't sure if it was a case of comparing a low level character with no skills and poor gear to one with a lot of specialization in skills and gear.

Also since I was playing in multiplayer games I could see a decent amount of, what seemed like, lag related issues with hitting and damaging in some situations.

The raiders are better at dodging and taking cover and they don't seem to charge in as straightforwardly as they did before.
But I'm only level 7 (8 maybe) so far, so there is a lot more to see before I get a good feel for it.