I honestly have no idea. My two current rune pages are AD Marks/GP Seals/MR Glyphs/GP Quints and Armor Marks/Seals/Quints & MR Glyphs.

I've found that having a built in GP10 is usually a massive advantage, while my "total defense" rune page is reserved for when I tank.

My primary concern is that spending my IP on a rune page won't actually add anything to my effectiveness; on the other hand, I don't know if there's any particular champ I want to buy.