Emphasis mine. If someone tries to take on a large, powerful predator in its specialty (predation) without using the human specialty (tool use) they are going to get badly hurt, and very likely killed. I doubt even someone like Masutatsu Oyama could have taken on a tiger barehanded.
Traps, projectile weapons, plate mail armor, spears, shields, and knives, in that order of priority.
If we're talking fantasy humanoids like gnolls, there is one bit of good news — bipeds have a large set of well-understood weaknesses that are relatively easy to exploit. You might also be able to exploit field of vision, depending. The bad news is that they'd be exploiting all of the same weaknesses on you, and copying your tool use.
(The other good news is that these creatures are largely impossible for structural reasons, so we're already in the realm of the ridiculous even sincerely considering them).
If you're forced to confront a toothed, clawed, big humanoid with your bare hands, then yes, grappling would probably be your best bet. A lot of locks and holds would effectively neutralize the advantages of teeth and claws. The problem is, first you'd have to go through the teeth and the claws.
It is if whatever you're up against also has training. It's like that old saw, "training in X can allow you to defeat bigger opponents and use your opponent's size against them." Well, yeah, unless your bigger opponent has the same training. Then you're not in such a great boat.
Crocodiles are easy. They bite harder than anything else alive, but the muscles they use to open their jaws are weak enough that you can hold them shut with rubber bands. Many animals have no such obvious weakness — trying something like that on something like a hyena, a bear, a tiger, a wild gaur or (god forbid) a hippo? That's a recipe for disaster.