Just got to the first big spoilery bit:

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Have to say, I more or less saw that coming from the moment they first announced that Hyperion was the villain for this game. You know, because of the whole "Guardian Angel is (in) a Hyperion satellite" thing after you kill the Destroyer.

On a semi-related note, I am so not buying the whole "Wilhelm nearly took down the Vault Hunters 1.0" thing it's not even funny. Even story/"canon"-wise, there's no way he's anything but a certifiable chump compared to the Destroyer, or General Knoxx, or Crawmerax, or M.I.N.A.C., or...