If you're running a Trade Empire based game, sure, I imagine it's pretty invaluable.
Beyond that, it's probably a well written and interesting sourcebook... But you can improvise pretty easily just from hearing "So there's this international Guild that trades useful stuff including slaves and drugs, negotiates with Fair Folk and the Shadowlands, and owns a city called Nexus used as their headquarters that the Core Book describes".
Just because it's a good book doesn't mean it's subject matter isn't fairly peripheral for the majority of games.