I believe Hellforged Relics say that to make high level ones a Yozi has to "sacrifice" a high circle Soul. So while those with a Sapience rating are not dead but bound, I don't think they can ever be released.
Though I doubt the Yozi would give up their 2nd/3rd circle souls without the ability to replace them, so I'd say making them into an artefact severs their connection to the Yozi (letting/forcing them to replace them with a similar but new soul), with their position as that artefact's little God allows them to sustain themselves once seperated without dissolving.