My last vampire character was a Ventrue who had to learn how to defend himself after Elysium got attacked by VII and he had to cower like a little girl because he had no fighting ability whatsoever. My character went ahead and bought a Colt Anaconda (one of the best midgame weapons in Vampire: Bloodlines) and backed it up with Combat Marksmanship 3 (the game died before I could get up to Combat Marksmanship 5). Along with some Kevlar for protection, my character was able to take down more VII vampires in the next combat encounter than the Gangrel Ancilla with Protean 3, from the safety of long range.