First off Custodians don't have gene-seed. They're made from a scaled-down version of the process that was used to create the Primarchs. They're mini-primarchs, so in this regard they were never mortal. Also, you assume that Constantin Valdor's occasionally attending councils of the High Lord of Terra is NOT the furthest extent of the Custodes' interactions with mortals. And you'd be right. They call it the Blood Games for a reason, mortals don't have the opportunity to train for millenia.
Comic 579 is up.
Coming down the pipeline, Ask the Custodes 9, featuring Ahriman the...uhh....something....Champion of Tzeentch, then Black Crusadin' pt 2.