You know, I have a hard time conceptualizing a true "alien" intelligence. Reason being is that any animal that procreates - as far as we know all but the Mule do - have certain characteristics in common. They protect their young (each in their own way, some like turtles in a very ineffective way for certain) and tend to choose providing resources for themself and their young over sharing them with others (see dogs killing other dogs pups, lions and cats do the same). Fact is, we have too much in common with these creatures possesing brains. We, in fact, do the same thing. Thats why it is easy to go fight a resource war with people who are not "like-us".

In order for a creatre to be possesed of an alien intelligence it must have its primal drives re-worked. Perhaps a plant intelligence or something that need not procreate. The undead would have made the best sense for delving into this territory, up until Malack. A vampire that has a drive to create more like himself.