A number of problems occurred when he took over 4e. He tried to turn it into some sick idea of what he believed was D&D, and that's coincidentally exactly when 4e disappeared from all the best-seller lists. Essentials was an utter failure, and he wrote what is widely considered the worst 4e supplements of all, Heroes of Shadow and BoVD.
Not to mention if you go back through the archives and follow all of his 5e design articles it's comedy gold. The transparency of the 5e design process demonstrated that Mearls had no idea what he was doing at basically any stage.
If 5e is functional, it is in spite of Mike Mearls, not thanks to him.