Seeing as how this thread came back from the dead (hopefully through a True Resurrection, and not some form of Necromancy), and given the fun I had making Illidan in the Video Game Antagonists thread, I think I'm gonna challenge myself a bit and try my had at FMA's Edward Elric.

Off the top of my head, I'm gonna be looking at either Half-Golem or Renegade Mastermaker, just gotta figure out a good way to emulate the Alchemy system. Binder comes to mind, as well as Runesmith, but we'll see what else sparks a creative thought with a bit more research.