That would be one of the strengths of RHoD. You could turn it into anything if by altering the details but not the plot.

But we shouldn't limit it to the Lord of Blades, there are plenty of other options out there. One of my ideas was to tell a story about the Orcs in Thar. You'd add Sons of Gruumsh into the mix, maybe a little bit from Mysteries of the Moonsea with the hammer of Vorbyx. And don't forget to raze Phlan.
Another idea I had was to make it about Hextor vs. Heironeous, with the aspect of Hextor descending from a colossal gate on an Acharonian cube.
It would also work perfectly in the Dragonlance campaign setting during the War of the Lance.

But what other options are out there?