But we're discussing drawbacks that don't exist within the fiction of the game. I can understand a dilemma where a character who becomes a werewolf or vampire is horrified at becoming the kind of monster they've been fighting all along, but put their quest for the cure on hold because their monstrous powers can be used for the greater good, but a situation where a condition in the fiction should make a character much stronger actually in mechanical terms cripples them would be really frustrating.