I don't have much in the way of advice, but this system has potential. I'm curious about poisons, though - how do you fight off toxins once they're in your system? I'm seeing a few possibilities here:

1. You have to take the damage to your health unless the toxin says otherwise. Much more lethal that I think you're going for.
2. You use Willpower. This would imply that Willpower is more than mental attacks, making Resist or something less mentally focused a better term.
3. You use a Skill/Trait? Honestly not sure how that'd work.

Is it one of these, or some other option I can't think of atm?