I can say that, having first watched them in numerical order, I do wish that I had seen them in release order. I think it would have been a different experience. Granted, I knew literally nothing about the Star Wars series when that happened. So, I had no idea who Obi Wan was, what this Anakin kid would do, anything. I'm sure that you all have gotten the general story via cultural osmosis, rather than the blank slate I was, but, I think, upon reflecting, that not bothering with the Prequel explanations for stuff initially makes the original trilogy stronger.
As a counterpoint, though, I think seeing the prequel movies first gave me a larger appreciation/tolerance of them than I see generally bandied about. I didn't find them half-bad.