Had a Pathfinder game where a young, high-strung and kinda useless Barbarian ended up forming a friendship with a young, laid-back and kinda useless Paladin, which grew so strong that some other members of the group started shipping it.

In another game, a young Chelaxian bastard of a noble house, the result of a regrettable fling with an Orc woman, who tried hard to live up to Chelaxian ideals while still influenced by his youth in an orc warcamp ended up forming a contentious friendship with an Andoran halfling and freedom fighter. A friendship which culminated in them rescuing a young slave together, for completely different reasons, and soon ended up in pseudo-parental mentor roles for the boy.
Then they regrettably both died, because mutated, intelligent strangler vines are absolute bull, and should not be fought in confined spaces whilst surrounded by animated object, like, what the hell were we thinking?