I have, and it can be fun, but the thing I hate most is the Stupid Laser Musket. Every so often it'll flat out miss, even as you watch the beam pass straight through the enemy face. It's depressing.

T-45 is interesting. It doesn't really have any legendary set pieces, but the Piezo Chest piece can be really handy in certain situations. I personally prefer T-60 myself, but T-45 is still plenty tough when maxed out.