The recent series that place Holmes in the 21st Century (as well as the movies that don't) are explicit in revisioning the detective. However, they attach to an under appreciated part of Holmes' character that prior adaptions often downplayed.
Here is a full length treatment of
Holmes' poor social skills. By the way, I cite that article only for the support it brings from the text that his social skills were rather poor, not to make the case that he was intended to have Aspergers or some form of autism.