I've never run a whole module several times, but there is a scenario I've run more than one.
The game wasn't D&D, but it was the first proper session I've run. I've mostly used it as beginner one-shot for kids as part of a "RPG discovery" holiday activity my town organized with the local RPG club.
Honestly, it didn't diminish my love for the scenario one bit. Each different player and each different PC bring something to the table that will lead to new situations, and that's without counting the things that hinges on random dice rolls or your own alterations. Even getting trolls as players can make the whole thing more memorable (though not more enjoyable).
It's just me, though, and it's something pretty short. I'm not sure it'll work the same for you, but I sure hope it does.