Quote Originally Posted by Mastikator View Post
PCs don't benefit from having alignments so you can skip all mortals having alignments.
Spells might benefit from having an "evil" or "good" tag, but you're better off replacing it with a faction system, instead of "smite evil" it's "smite member of opposing faction/supernatural entity forbidden by my faction".
Outsiders and cosmology can also be factions instead of alignments, factions can have ideologies.

Alignments are just a training wheel that quickly becomes an obstacle you have to work around.
I strongly disagree with most of this, but will agree that alignments are a tool, and not every tool; whether they're a good tool or not depends on how you use them. Either way, they're not an indispensable tool, so you don't have to use them, and indeed, as pointed out, many RPG systems that aren't DnD or based off of DnD don't use them. If you want to dispose of them in a game system that does use them, you'll likely need to make some adjustments to other rules, but exactly what needs to be adjusted depends on the specific system, the setting, and your and your players intent/preferences.