Originally Posted by
Mastikator
PCs don't benefit from having alignments so you can skip all mortals having alignments.
Spells might benefit from having an "evil" or "good" tag, but you're better off replacing it with a faction system, instead of "smite evil" it's "smite member of opposing faction/supernatural entity forbidden by my faction".
Outsiders and cosmology can also be factions instead of alignments, factions can have ideologies.
Alignments are just a training wheel that quickly becomes an obstacle you have to work around.