The rapture has occurred on humanity multiple times before

[Bohandas]

That is an horrific lovecraftian scenario.
I think it means I must make in this setting a party set on destroying all the cultists of that evil evilly evil entity(and kill that entity if possible).
And also kill all the other gods and their cultists on the other spheres.
while setting up a religion about faith in the rules of physics and the existence of space time or something like that to fix the problem that without the evil parasites filled with evil intentions the universes starts disappearing.

More warhammerey than lovecraftian

EDIT:

Also kimd of matrixey