Sure. 21st century humans dump Str all the time, and both Str and Cha have enough mechanical implications that dumping them is still interesting. A Str 6 Sharpshooter can still fight just fine with a rapier, but can't use a Vorpal Longsword very well, can't grapple well, and is subpar are getting out of grapples; a Cha 6 Druid with no social skill proficiencies will probably be unable e.g. to talk the sheriff into letting him have a word with the other PCs when they're in jail. And that's fine! The game is all about meaningful choices, and being bad at certain things is a choice. Besides, watching the druid player roleplay an awkward persuasion attempt is good fun for everybody at the table.
I dunno, I didn't start the thread and I don't really agree with the OP's goals or approach. My only complaint about vanilla PHB rules is that they fail to make high-Int non-wizards sufficiently interesting.Since those are also minor saves and not important to characters who don't need them for their class.
Is this thread really a big complaint about the lack of focus on Int?