In D&D? Not as much... in fact, the ones that do exist tend to be stereotypes, themselves (q.v. dwarves and orcs and elves, gnomes and goblins and kobolds).

Outside of D&D? It tends to be a bigger issue. The game worlds, and the games themselves, don't have that assumption of cosmopolitanism that D&D has fostered since 3.x. I tend to de-emphasize gender discrimination, but that's for power structure ideals, and I also take a look at a lot of other prejudices through a lens of "What makes sense for the world described here", rather than assuming all the prejudices from our world automatically show up in fantasy worlds.

The Mod Wonder: As an aside, I had trouble answering this without getting into the specifics of real-world religion, politics, and suchlike. Be very careful with your answers; this is a good question, but it will be hard to answer on the right side of the rules. Just FYI.