Oh, I know a good one. Oracle with the Site-Bound curse is effectively restrained to a single pretty small location, forever. If you want, you can even stick a single level of this onto any other "worst" build to make it even worse.
Vigilante with the Brute archetype, as well as the Antipaladin, are also hilariously detrimental to any party they're in. And then there's the Monk with Vow of Poverty, which is one of the worst deals for your character in the game.
So, let's go with Oracle 1 / Vigilante 1 / Antipally 1 / Oozemorph 1 / Monk 1 / Kinny 15. That's the most restrictions I can think of to tack onto the worst class in the game.