As in... in cinemas? If so I would recommend Burn after Reading. It's very funny, perhaps not on par with some of the other Coen Brothers' films but still, very very good. 'How to lose friends and alienate people' is apparently pretty *ahem* crummy, as a friend put it (this friend is a known Pegg-fan, and even that couldn't save it)
Other films... I heartily recommend I <3 Huckabees, as films about existential angst go, I'd rate it as the best. Admittedly it's not to everyone's taste (only one of my friends likes it, the rest (who have actually seen it) hate it)