An episodic style could absolutely work for Fallout, Star Trek Strange New Worlds is episodic and also fantastic. But if anything episodic shows depend even more heavily on character interaction because the plot gets basically wrapped up at the end of every episode. Aside from the occasional two-parter or season finale, you aren't gonna be excited for the next installment because you need to know what plot thing happens next, but because you're invested in the characters.

Which kinda means you need a very strong, drama generating core cast, quite possibly am ensemble. CRPGs aren't written this way, because the purpose of companions isn't to be co-main characters, but to give you cool people telling you how awesome you are and provide some more fun stuff to do.