It's Hulk: Ultimate Destruction.
Like, no joke. This is Hulk: Ultimate Destruction with a disguise mechanic.
Even the developers admit that yeah, it's Hulk: Ultimate Destruction.
If they ever do a Spider-Man 2 game again, with the web slinging, it'll just win so many awards.
(For the record, I love Prototype. Followed it as soon as it was announced, played it through a couple times. New Game+ is therapeutic.)