Nicodemus

"Oh, I'm not asking out of curiosity. I'm asking because a few years ago, I used a piece of the Shroud to create copies of every disease known to mankind, and infect a subject with said diseases in their terminal stages-simultaneously. I did plan to use the actual Shroud to infect a far greater amount of people with it, but I was...interrupted. But that is the past. I'm telling you this now because all your precious samples have just been contaminated."

Whilst Nicodemus has been talking, he has been fiddling with the string; at the end of his little monologue, he tears the thread in half, releasing the spell, and irrevocably corrupting all of Carlisle's experiments. From the one barely alive to the neatly labeled organs.